Immortalized Human Endocervical Epithelial Cells - HPV E6/E7 (A2EN)

The endocervical epithelium lines the endocervix in the female reproductive tract, separating sterile and microbe-rich regions from one another. Since the endocervix is a target for sexually transmitted organisms such as Chlamydia trachomatis and Neisseria gonorrhoeae, the endoecervical epithelial cells play an important role in both host defense and reproduction. The Immortalized Endocervical Epithelial Cells – HPV E6/E7 is unique in that it can be polarized to exhibit distinct apical and basolateral membrane domains and that it retained its ability to respond to hormone and microbial stimulus. A2EN cells serve as an excellent model to further characterization of pathogen-host interactions on sexually transmitted infections.