Immortalized Rat Retinal Müller Cells (rMC-1)
| Specifications | |
|---|---|
| Cell Category: | Immortalized Cell Lines |
| Organism: | Rat |
| Tissue of Origin: | Retina |
| Morphology: | Flattened |
| Culture Properties: | Adherent |
| Immortalization Method: | Serial passaging and Calcium Phosphate mediated transfection with simian virus 40 (SV40) DNA |
| Marker: | GFAP, CRALBP |
Propagation
Please contact us for propagation details.
Additional Information
Müller cells are glial cells in the vertebrate retina responsible for the homeostatic and metabolic support of retinal neurons. Under pathological conditions, a subset of Müller cells may differentiate to neural progenitor/stem cells which regenerate lost photoreceptors and neurons.
The rMC-1 cell line is derived from stable transformation of SV40 antigen into primary rat retinal Müller cells. The rMC-1 cells resembles its primary counterpart and expresses reactive gliosis marker GFAP and Müller cell-specific marker CRALBP, though at lower levels when compared to the primary cells. This cell line enables mammalian retinal function research, as well as facilitates gene expression studies in Müller cells-neuron and/or Müller cells-endothelial cell interactions.
The rMC-1 cell line is derived from stable transformation of SV40 antigen into primary rat retinal Müller cells. The rMC-1 cells resembles its primary counterpart and expresses reactive gliosis marker GFAP and Müller cell-specific marker CRALBP, though at lower levels when compared to the primary cells. This cell line enables mammalian retinal function research, as well as facilitates gene expression studies in Müller cells-neuron and/or Müller cells-endothelial cell interactions.
Commercial Price Disclaimer
Researchers at for-profit organizations and corporations, please contact us for pricing of this item.
Genetically Modified Organism (GVO)
See General Terms.
- Catalog Number
T0576-GVO-ABM - Supplier
ABM - Size
- Shipping
Dry Ice
- Price
- Please inquire
