Immortalized Human Hair Follicle Dermal Papilla Cells - HPV E6/E7
| Specifications | |
|---|---|
| Cell Category: | Immortalized Cell Lines |
| Organism: | Human |
| Tissue of Origin: | Hair Follicle |
| Morphology: | Multipolar |
| Culture Properties: | Adherent |
| Immortalization Method: | Serial passaging and transduction with recombinant lentiviruses carrying HPV E6/E7 gene. |
Propagation
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Additional Information
Human Hair Follicle Dermal Papilla cells are highly active mesenchymal cells isolated from the hair papilla embedded in extracellular matrix of scalp hair follicles. Dermal Papilla Cells play a significant role in controlling the hair growth cycle and production by involving in the epithelial-mesenchymal interaction of hair follicle cells. Their survival is regulated by signal transduction pathways such as ERK and Akt. These cells can be used for development and evaluation of hair growth products and identifying cell populations within the hair follicle. In addition, they can be used for in vitro screening of androgen blocking reagents since they have androgen receptors.
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Genetically Modified Organism (GVO)
See General Terms.
Product Citations
- Kang, H., & Lee, S.-G. (2024) Pharmacological activities of extracts from different parts of Cirsium japonicum var spinossimum Tropical Journal of Pharmaceutical Research
- Choi, B. Y. (2023) Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation Current Topic in Lactic Acid Bacteria and Probiotics
- Ei, Z. Z., Racha, S., Yokoya, M., Hotta, D., Zou, H., & Chanvorachote, P. (2023) Simplified Synthesis of Renieramycin T Derivatives to Target Cancer Stem Cells via β-Catenin Proteasomal Degradation in Human Lung Cancer Marine Drugs
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T0505-GVO-ABM - Supplier
ABM - Size
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