Immortalized Human Dopaminergic Neuronal Precursor Cells (LUHMES)
| Specifications | |
|---|---|
| Cell Category: | Immortalized Cell Lines |
| Organism: | Human |
| Tissue of Origin: | 8-week-old fetal human ventral mesencephalon |
| Morphology: | Flattened|Dendritic processes |
| Culture Properties: | Adherent |
| Immortalization Method: | Conditional immortalization by tetracyclin-controlled transduction with retrovirus carrying v-myc genes |
| Marker: | DAT, VMAT-2, TH, α-SYN, β-III tubulin |
| Donor Age: | 8 weeks old |
Propagation
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Additional Information
The Immortalized Human Dopaminergic Neuronal Precursor Cells, also known as the Lund Human Mesencephalic (LUHMES) cell line, is a subclone of the tetracycline-controlled, v-myc-overexpressing human mesencephalic-derived cell line MESC2.10. This cell line is unique in that it can be differentiated to acquire a dopaminergic neuron-like phenotype under appropriate growth conditions. LUHMES expresses functional dopamine transporter (DAT), vesicular monoamine transporter (VMAT-2), tyrosine hydroxylase (TH) and the neuronal form of β-III tubulin after differentiation. In addition to retaining dopaminergic neuronal-specific markers, LUHMES also exhibit electrophysiological properties, thus making this cell line a valuable neuronal model for neurodevelopmental studies, disease modelling and neuropharmacology.
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Genetically Modified Organism (GVO)
See General Terms.
Product Citations
- Matsushita, I., Izumi, H., Ueno, S., Hayashi, T., Fujinami, K., Tsunoda, K., Iwata, T., Kiuchi, Y., & Kondo, H. (2023) Functional Characteristics of Diverse PAX6 Mutations Associated with Isolated Foveal Hypoplasia Genes
- Nishi, K., Izumi, H., Tomonaga, T., Nagano, C., Morimoto, Y., & Horie, S. (2023) IL-6-Mediated Upregulated miRNAs in Extracellular Vesicles Derived from Lund Human Mesencephalic (LUHMES) Cells: Effects on Astrocytes and Microglia Biomolecules
- Rueda-Gensini, L., Serna, J. A., Rubio, D., Orozco, J. C., Bolaños, N. I., Cruz, J. C., & Muñoz-Camargo, C. (2023) Three-dimensional neuroimmune co-culture system for modeling Parkinson’s disease microenvironments in vitro Biofabrication
- Seki, I., Izumi, H., Okamoto, N., Ikenouchi, A., Morimoto, Y., Horie, S., & Yoshimura, R. (2023) Serum Extracellular Vesicle-Derived hsa-miR-2277-3p and hsa-miR-6813-3p Are Potential Biomarkers for Major Depression: A Preliminary Study. International Journal of Molecular Sciences
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T0284-GVO-ABM - Supplier
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