Immortalized Human Astrocytes, fetal - hTERT
| Specifications | |
|---|---|
| Cell Category: | Immortalized Cell Lines |
| Organism: | Human |
| Tissue of Origin: | Brain |
| Morphology: | Multipolar |
| Culture Properties: | Adherent |
| Immortalization Method: | Serial passaging and transduction with recombinant lentiviruses carrying hTERT gene. |
| Donor Age: | 18 weeks gestation |
| Donor Gender: | Female |
Propagation
Please contact us for propagation details.
Additional Information
Astrocytes are glial cells found in the brain and spinal cord that play a critical role in maintenance, support, and repair of nervous tissue. Astrocytes have also been implicated in various pathological processes. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is also influenced by astrocyte surface molecule expression and trophic factor release. These cells can serve as valuable in vitro model for exploring the diversity of astrocytes functions.
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Genetically Modified Organism (GVO)
See General Terms.
Product Citations
- Jenna R. Gale, Karen Hartnett-Scott, Madeline M. Ross, Paul A. Rosenberg, Elias Aizenman (2023) Copper induces neuron‐sparing, ferredoxin 1‐independent astrocyte toxicity mediated by oxidative stress Journal of Neurochemistry
- Minteer, C. J., Thrush, K., Gonzalez, J., Niimi, P., Rozenblit, M., Rozowsky, J., Liu, J., Frank, M., McCabe, T., Sehgal, R., Higgins-Chen, A. T., Hofstatter, E., Pusztai, L., Beckman, K., Gerstein, M., & Levine, M. E. (2023) More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome Science Advances
- Nishi, K., Izumi, H., Tomonaga, T., Nagano, C., Morimoto, Y., & Horie, S. (2023) IL-6-Mediated Upregulated miRNAs in Extracellular Vesicles Derived from Lund Human Mesencephalic (LUHMES) Cells: Effects on Astrocytes and Microglia Biomolecules
- Zeb, S., Ye, H., Liu, Y., Du, H.-P., Guo, Y., Zhu, Y.-M., Ni, Y., Zhang, H.-L., & Xu, Y. (2023) Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine’s inhibitory effects on necroptotic kinases Frontiers in Pharmacology
- Catalog Number
T0281-GVO-ABM - Supplier
ABM - Size
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