Human R-Spondin 1 / RSPO1 Protein
| Specifications | |
|---|---|
| Category: | Bio-Markers & CD Antigens |
| Molecular Weight: | 28.7 kDa |
| Tag: | C-10×His |
| Label / Conjugate: | N/A |
| Source: | Human R-Spondin 1, His Tag (RS1-H4221) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Ala 263 (Accession # Q2MKA7-1). |
| Purity: | 95% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | RSPO1,CRISTIN3,FLJ40906,RP11-566C13.1,R-spondin-1 |
| Organism: | Human |
| Accn. No.: | Q2MKA7-1 |
Sequence Information
Ser 21 - Ala 263
Background
R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.
Product Citations
- Park JH, Choi AJ, Kim SJ, Cheong SW, Jeong SY (2016) AhR activation by 6-formylindolo [3, 2-b] carbazole and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin inhibit the development of mouse intestinal epithelial cells Environ Toxicol Pharmacol
- Das I, Png CW, Oancea I, Hasnain SZ, Lourie R, Proctor M, Eri RD, Sheng Y, Crane DI, Florin TH, McGuckin MA. (2013) Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins J Exp Med
Price
505,00 €
