Recombinant Human ACVR2B/ActivinR-IIB Protein (His Tag)(Active)
| Specifications | |
|---|---|
| Molecular Weight: | 15 kDa |
| Tag: | C-His |
| Source: | HEK293 Cells |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per µg as determined by the LAL method. |
| Activity: | 1.Measured by its ability to bind biotinylated Human INHBA-his in functional ELISA.2. Measured by its ability to bind biotinylated Mouse INHBA-his in functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 µg/mL in the presence of 10 ng/mL recombinant Activin A. |
| Format: | Lyophilized from sterile PBS, pH 7.4 |
| Additional Information | |
|---|---|
| Synonyms: | Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B;Bone Morphogenetic Protein Receptor Type-2; BMP Type-2 Receptor; BMPR-4; Bone Morphogenetic Protein Receptor Type II; BMP Type II Receptor |
| Organism: | Human |
| Accn. No.: | NP_001097.2 |
Sequence Information
Met 1-Thr 134
Background
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
- Catalog Number
PKSH031742-100ug-ELS - Supplier
Elabscience - Size
- Shipping
RT
Price
361,00 €
