Recombinant Human OPG protein (GST,His tag)
| Specifications | |
|---|---|
| Molecular Weight: | 55.6 kDa |
| Tag: | N-GST & C-His |
| Source: | E.coli |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 10 EU/mg of the protein as determined by the LAL method. |
| Format: | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Additional Information | |
|---|---|
| Synonyms: | OCIF;OPG;Osteoclastogenesis inhibitory factor;Osteoprotegerin;PDB5;TNFRSF11B;TR1;Tumor necrosis factor receptor superfamily member 11B |
| Organism: | Human |
| Accn. No.: | O00300 |
Sequence Information
Glu 22-Glu 300
Background
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between
- Catalog Number
PDEH101068-20ug-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
Price
194,00 €
