TNF-alpha Mouse ELISA Kit

TNF-alpha is the prototypic pro-inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells. TNF-alpha is also important for resistance to infection and cancers. It is central to host defense and inflammatory responses but under certain circumstances also triggers necrosis or apoptosis. Its pleiotropic effects often lead to opposing outcomes during the development of immune-mediated diseases such as cancer, Alzheimer’s, inflammatory bowel disease, Crohn’s Disease, ulcerative colitis, rheumatoid arthritis, psoriatic arthritis, psoriasis, and noninfectious uveitis. As a result, a number of TNF-alpha therapies and biologic agents have been FDA approved.