Human IL-31 Protein, premium grade
| Specifications | |
|---|---|
| Category: | Cytokines&Growth Factors |
| Molecular Weight: | 15.8 kDa |
| Tag: | Native |
| Label / Conjugate: | N/A |
| Source: | Human IL-31 Protein, premium grade (IL1-H5219) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Thr 164 (Accession # Q6EBC2-1). |
| Purity: | 90% |
| Endotoxin Level: | 0.1 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Human |
| Accn. No.: | Q6EBC2-1 |
Sequence Information
Ser 24 - Thr 164
Background
IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
Price
283,00 €
