Alexa Fluor 488-Labeled Human CD27 Ligand / CD70 Protein, His TagStar Staining
| Specifications | |
|---|---|
| Category: | Fluorescent labeled protein |
| Molecular Weight: | 63.9 kDa |
| Tag: | N-10×His |
| Label / Conjugate: | AF488 Labeled |
| Source: | Alexa Fluor 488-Labeled Human CD27 Ligand Protein, His Tag (CDL-HA247) is produced via conjugation of AF488 to Human CD27 Ligand Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human CD27 Ligand Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1). |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Human |
| Accn. No.: | P32970-1 |
Sequence Information
Ser 52 - Pro 193
Background
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
Price
3.505,00 €
