Alexa Fluor™ 488-Labeled Mouse CD3 epsilon Protein, Fc Tag
| Specifications | |
|---|---|
| Molecular Weight: | 36.0 kDa |
| Tag: | C-Fc |
| Source: | Alexa Fluor 488-Labeled Mouse CD3 epsilon Protein, Fc Tag (CDE-MA256) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 108 (Accession # P22646). It is the Alexa Fluor 488 labeled form of Mouse CD3 epsilon Protein, Fc Tag. |
| Purity: | 90% |
| Endotoxin Level: | 1.0 EU per μg |
| Format: | Powder |
| Additional Information | |
|---|---|
| Organism: | Mouse |
| Accn. No.: | P22646 |
Sequence Information
Asp 23 - Asp 108
Background
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Price
588,00 €
