Anti-ds-DNA IgA/IgG/IgM Screen ELISA

Most individuals with SLE display IgG class antibodies against dsDNA. These autoantibodies are associated with lupus nephritis. In addition, approximately 30% of individuals with SLE develop IgA class anti-dsDNA antibodies. It has been suggested that the presence of these IgA class antidsDNA antibodies may define a certain subset of individuals with SLE. Studies demonstrated the association of this subclass with certain parameters of the disease activity, such as elevated erythrocyte sedimentation rate, or the consumption of complement component C3, as well as the clinical parameters of cutaneous vasculitis, acral necrosis, and erythema. No association was found for nephritis and arthritis.