Hi-C & Hi-ChIP Chomosomal Structure Analysis

Explore Arima Hi-C Technology

Understand how spatial relationships in genome structure impact gene regulation, cellular development, and disease processes.

Arima Hi-C is a proximity ligation method that captures the organizational structure of chromatin in three dimensions, where genomic sequences that are distal to each other in linear distance can be closer to each other in the 3D space. The high-resolution, genome-wide map of interacting genetic loci that is generated from Hi-C data can be used across multiple genomic applications, including identification of promoter-enhancer interactions for gene regulation studies, detection of structural rearrangements, and scaffolding contigs for genome assemblies to define chromosomes de novo.

Use the most advanced Hi-C technology to power your discoveries with unparalleled access to the sequence & structure of any genome.

Hi-C - Accurate and Reproducible Chromosome Conformation Capture

The 3D structure of the genome plays an essential role in gene expression. The arrangement of chromosomal loops brings critical regulatory elements into close proximity, resulting in altered function.

By combining Arima Hi-C proximity ligation with NGS you can reveal high-resolution maps of these chromatin interactions to identify promoter-enhancer interactions, link non-coding disease-associated variants to target promoters, and uncover how perturbations in genome conformation impact gene regulation in disease.

Hi-C Structural Variant Detection

Detect structural variants in the genome using the Arima-HiC+ FFPE kit. With Arimas robust and easy-to-use workflow, your formalin fixed paraffin embedded (FFPE) samples can yield critical genomic information — regardless of sample age.

Hi-Chip - Map the Regulatory Landscape with HiChIP

Combine the power of Arima HiC+ with chromatin immunoprecipitation (ChIP) to discover active gene regulatory interactions so you can better understand gene regulation, study disease mechanisms, and identify novel therapeutic targets.

Hi-C Genome Assembly - Generate Highly Contiguous Assemblies by Incorporating Long-range Sequence Information into your NGS Data

Arima Hi-C is a proximity ligation sample preparation method that detects spatially proximal DNA interactions within cells. This approach lets you leverage the 3D dimensional chromosome folding structure and preserve long-range sequence information prior to sequencing with standard library prep and NGS workflows.

Mapping the architecture of the genome through DNA interactions uniquely captures biological properties of chromosomes within cells, providing novel insights into the structure and function of the genome.

Capture Hi-C - Capture What Matters With High Resolution Hi-C

Use Arima-HiC+ to understand gene regulation and epigenetic features in regions of interest so you can identify novel biomarkers and therapeutic targets. The Arima-HiC+ Promoter Capture Panels help you to gain deeper insights on promoter interactions.