CUTANA Fiber-Seq Assays

A multiomic assay that goes beyond ATAC-seq

CUTANA™ Fiber-seq is a groundbreaking multiomic approach that combines a simple labeling strategy with long-read sequencing. This method captures multiple layers of information—including chromatin accessibility, DNA methylation, protein footprints, and genetic variants — from ONE experiment. The result is a high-resolution view of chromatin regulation that cannot be achieved with traditional short-read approaches.

• Multiomic insights in one assay 
• User-friendly resources
• Easy workflow integration
• Powered by Hia5 6mA methyltransferase
• Stringent quality control 
  
  

Weaving together a complete picture of chromatin regulation requires methods that can capture multiple chromatin features at once and at high resolution. Current approaches fall short, often requiring the integration of several different assays that slow research and use up valuable resources. Many of these assays also rely on short-read sequencing, which misses important insights in complex regions of the genome frequently tied to disease. Even widely used methods like ATAC-seq provide only a rough view of chromatin accessibility, and while this method has been shown to footprint proteins, doing so requires such deep sequencing that it is impractical for most studies. Fiber-seq overcomes all these challenges.

Questions?

Connect with us today to get started on your Fiber-seq sequencing experiment.

How Fiber-seq works

Because Fiber-seq does not require PCR amplification or antibodies, the workflow avoids common biases and reduces experimental complexity. Further, long-read sequencing enables better coverage of the genome (i.e., repetitive or structurally complex genomic regions) and allele-specific profiling of both genetic and epigenetic features (i.e., haplotype phasing).

Any Questions Left?

Contact us for assistance to get started on your Fiber-seq sequencing experiment.