SKU: IT1-H52W6-1mg-AC
Human Integrin alpha 2 beta 1 (ITGA2 & ITGB1) Heterodimer Protein
Human
RT
Specifications
| Specification | Details |
|---|---|
| Label | Unconjugated |
| Host | HEK293 |
| Molecular Weight | 127.6 kDa (ITGA2) & 83.7 kDa (ITGB1) |
| Tag | C-10×His | Native |
| Purity | 95% |
| Endotoxin Level | 1.0 EU per μg |
| Format | Powder |
| Synonyms | Integrin alpha 2 beta 1,ITGA2 & ITGB1 |
| Organism | Human |
| Accession No. | P17301-1 (E534K) (ITGA2) & P05556-1 (ITGB1) |
| Sequence Info | Tyr 30 - Thr 1132 (ITGA2) & Gln 21 - Asp 728 (ITGB1) |
| Background | Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection. |
Resources
PDF
Datasheet
Catalog Number
IT1-H52W6-1mg-AC
Name
Human Integrin alpha 2 beta 1 (ITGA2 & ITGB1) Heterodimer Protein
Price(1 mg)
Pack Size