Thymidine-5'-O-(α,β-methylene)diphosphate sodium

Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM). It serves as a precursor in the synthesis of α,β-methylene-2’-deoxythymidine 5’-triphosphate, which is a non-cleavable substrate for DNA polymerase.