2'3'-Cyclic GAMP ELISA Kit

2',3'-Cyclic guanosine monophosphate-adenosine monophosphate was the first cyclic di-nucleotide found in metazoa. 2',3'-cGAMP is also referred to as a noncanonical cGAMP due to the presence of the atypical 2',5' phosphodiester linkage between the guanosine and the adenosine. 2',3'-cyclic GAMP is a novel second messenger in innate immunity that regulates type I interferon (IFN) production. Produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm binding to cGAS, cGAMP binds to the stimulator of interferon genes (STING). Subsequently STING induces the TBK1-IRF3-dependent production of IFN-b. This cGAS-cGAMP-STING pathway has been shown to play a critical role in pathogen detection and physiological conditions such as metabolic dysregulation, autoimmunity, and cancer.