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RNP Delivery

Easily accessible genome editing by RNA-guided nucleases has transformed all disciplines of molecular biology, and especially the potential for development of therapeutics is tremendous. Major problems are the fidelity of the system (off-targets), and the efficiency and targeting to specific cell types.
Direct delivery of ribonucleoprotein (RNP) complexes increases fidelity, and also provides a certain degree of control, as it’s transient and with no risk of integration into the cell genome.

Compared to DNA-based approaches, RNP delivery enables faster and more efficient genome editing, and it offers a powerful alternative for difficult cells.
Using Cas9 protein and gRNA complexes (RNP) is the preferred method due to less off-target effects and leaving no foot-print.

CRISPR RNP Delivery

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• No need to use the cell machinery
• CRISPR components directly active upon transfection
• Skips the assembly step in the cytosol
• Active endosome escape leading to high CRISPR RNP transfection efficiency
• Better control of the Cas9 activity

 

 

Description Cat# Size Price    
CRISPR-Fectin transfection reagent EF015-GC 1ml 323 € DETAILS   Add to Cart 
CRISPR-Fectin transfection reagent EF016-GC 3ml 624 € DETAILS   Add to Cart 
Viromer CRISPR Transfection Reagent for RNP TT100311-OR 500 rxns 325 € DETAILS   Add to Cart 

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