Glycosylation is the addition of sugar molecules onto cellular proteins, lipids, and polysaccharides that results from co- and post-translational modification. The Glycocalyx, literally meaning ‘sugar coat’, is an extracellular polymeric coating surrounding many prokaryotic and eukaryotic cells. It consists of glycoproteins, glycolipids, proteoglycans and glycosaminoglycans. Changes of the glycosylation on the cell surface have been linked to numerous cellular diseases, most notably in several cancers. Understanding the changes that occur in the cellular process of molecule glycosylation can unveil new biomarkers of disease or pave the way for new drug targets.
However, detection tools for the research of glycobiology are currently very limited.
Taking advantage of advancements in microarray technology developed for antibody arrays, our partner RayBiotech developed glycobiology arrays to help researchers
• Identify and profile the glycans in their samples
• Determine whether their biomarker of interest has glycan moieties
• Find specific glycan binding ligands in biological samples