Recombinant Mouse P-selectin/CD62P Protein (Fc Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 99.5 kDa |
| Tag: | C-Fc |
| Source: | Human Cells |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg as determined by the LAL method. |
| Format: | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Additional Information | |
|---|---|
| Synonyms: | P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; PADGEM |
| Organism: | Mouse |
| Accn. No.: | Q01102 |
Sequence Information
Trp42-Ala709
Background
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
Price
164,00 €
