Recombinant Mouse FGF21 Protein(Trx Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 40.0 kDa |
| Tag: | N-Trx |
| Source: | E.coli |
| Purity: | > 80% as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 10 EU/mg of the protein as determined by the LAL method |
| Format: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Additional Information | |
|---|---|
| Synonyms: | Fibroblast Growth Factor;Fibroblast Growth Factor 21;FGF-21;Fgf21 |
| Organism: | Mouse |
| Accn. No.: | Q9JJN1 |
Sequence Information
Ala29-Ser210
Background
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Price
2.338,00 €
