Recombinant Mouse CD300a/LMIR1 Protein (Fc Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 44.3 kDa |
| Tag: | C-Fc |
| Source: | Human Cells |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg as determined by the LAL method. |
| Format: | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Additional Information | |
|---|---|
| Synonyms: | CD300a;CD300a antigen;CMRF35H9; CD300a molecule; leukocyte immunoglobulin-like receptor;CD300 antigen-like family member A; CMRF35-like molecule 8;NK inhibitory receptor; Immunoglobulin superfamily member 12; IRp60;Inhibitory receptor protein 60; CLM8; CMRF-35H; IGSF12; IRC1; IRC2; LMIR1;CLM-8;MAIR-I;Clm8;MAIR-I;MAIR-Ia;mcpir1;MMAC8;Pigr4 |
| Organism: | Mouse |
| Accn. No.: | Q6SJQ0 |
Sequence Information
Leu28-Arg183
Background
LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.
Price
233,00 €
