Recombinant Human Vitronectin/VTN Protein (His Tag)(Active)
| Specifications | |
|---|---|
| Molecular Weight: | 53.4 kDa |
| Tag: | C-6His |
| Source: | Human Cells |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per µg as determined by the LAL method. |
| Activity: | Measured by the ability of the immobilized protein to support the adhesion of Jurkat cells. |
| Format: | Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
| Additional Information | |
|---|---|
| Synonyms: | Vitronectin; VN; S-Protein; Serum-Spreading Factor; V75; VTN |
| Organism: | Human |
| Accn. No.: | P04004 |
Sequence Information
Asp20-Leu478
Background
Human Vitronectin/VTN is a cell adhesion and spreading factor. It can be found in the blood and the extracellular matrix (ECM). Vitronectin interacts with glycosaminoglycans and proteoglycans. The multimeric Vitronectin can efficiently bind to and incorporate into the ECM; Vitronectin can support cell adhesion through binding to various integrins and other proteoglycans. Vitronectin can be recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecular. It can as a inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Vitronectin contains an endogenous cleavage site; plus cleavage sites for elastase; thrombin; and plasmin.
Price
164,00 €
