Recombinant Human HGF Protein (His Tag)(Active)
| Specifications | |
|---|---|
| Molecular Weight: | 26&53.7&80.7 kDa |
| Tag: | C-6His |
| Source: | Human Cells |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per µg as determined by the LAL method. |
| Activity: | Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells. The ED50 for this effect is 0.3-1.5 ng/ml. |
| Format: | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0. |
| Additional Information | |
|---|---|
| Synonyms: | Hepatocyte growth factor;HPTA;HGF;SF;Scatter factor;Hepatopoietin-A |
| Organism: | Human |
| Accn. No.: | P14210 |
Sequence Information
Gln32-Ser728
Background
Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It belongs to the peptidase S1 family and Plasminogen subfamily, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.
Price
233,00 €
