Recombinant Human GFER Protein (His Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 17.3 kDa |
| Tag: | N-6His |
| Source: | E.coli |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per µg as determined by the LAL method. |
| Format: | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Additional Information | |
|---|---|
| Synonyms: | FAD-linked sulfhydryl oxidase ALR;GFER;Augmenter of liver regeneration;hERV1;Hepatopoietin;GFER;ALR;HERV1;HPO |
| Organism: | Human |
| Accn. No.: | P55789 |
Sequence Information
Met 1-Asp125
Background
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
Price
125,00 €
