Osteopontin ELISA

Osteopontin is a member of the SIBLING (Small Integrin-Binding Ligand N-linked Glycoprotein) family. It is 300 amino acids in length, is expressed in a variety of tissues and can be post-translationally modified. The full-length protein is detectable in plasma, urine and breast milk. Serum osteopontin is prone to cleavage during clotting and therefore is not a preferred sample type. Osteopontin plays a role in a number of physiological functions including bone remodeling, immune function, apoptosis and cell signaling. Studied across a range of therapeutic areas, there is interest in identifying clinical applications for osteopontin as it relates to cancer, autoimmune disease, bone disease, renal disease, allergy and asthma, among others.