Human Tumor Necrosis Factor alpha (TNF alpha)
| Specifications | |
|---|---|
| Molecular Weight: | 17,5 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 2 ng/mL |
| Activity Assay: | Cytolysis of mouse L929 cells in the presence of Actinomycin D |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 10 mM Sodium Phosphate, pH 7.5 |
| Additional Information | |
|---|---|
| Synonyms: | TNFSF2, Cachectin, DIF, Necrosin, Cytotoxin, Cachexin, TNF |
| Organism: | Human |
| Accn. No.: | P01375 |
Sequence Information
MVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELRDNQLV VPSEGLYLIY SQVLFKGQGC PSTHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINRP DYLDFAESGQ VYFGIIAL
Background
Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNFa signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNFa functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.
- Catalog Number
100-111-10UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
96,00 €
