Human Transforming Growth Factor alpha (TGF-alpha)
| Specifications | |
|---|---|
| Molecular Weight: | 5,6 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 2 ng/mL |
| Activity Assay: | BALB/c 3T3 proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Additional Information | |
|---|---|
| Synonyms: | TGF-alpha, EGF-like TGF, ETGF, TGFA, TGF type 1 |
| Organism: | Human |
| Accn. No.: | P01135 |
Sequence Information
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Background
Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling. TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation. In the gastric mucosa, TGF-α production inhibits gastric acid secretion and therefore plays a central role in the pathogenesis of the stomach syndrome Ménétrier's disease. TGF-α is also produced in adult macrophages, brain cells, keratinocytes, and is widely expressed in cancer cells.
- Catalog Number
100-209-500UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
852,00 €
