Human Interleukin-15 (IL-15)
| Specifications | |
|---|---|
| Molecular Weight: | 12,9 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥97% |
| Activity: | 1 ng/mL |
| Activity Assay: | CTLL-2 cell proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 10 mM Sodium Bicarbonate, pH 8.5 |
| Additional Information | |
|---|---|
| Synonyms: | IL-T |
| Organism: | Human |
| Accn. No.: | P40933 |
Sequence Information
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Background
Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.
- Catalog Number
100-86-100UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
623,00 €
