Human Interleukin-1 alpha (IL-1 alpha / IL-1F1)
| Specifications | |
|---|---|
| Molecular Weight: | 18 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 0.05 ng/mL |
| Activity Assay: | D10.G4.1 cell proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 10 mM Sodium Phosphate, pH 7.5 |
| Additional Information | |
|---|---|
| Synonyms: | IL-1F1, FAF, BAF, LEM, LAF |
| Organism: | Human |
| Accn. No.: | P01583 |
Sequence Information
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Background
Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.
- Catalog Number
100-173-100UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
824,00 €
