Human Granulocyte Colony Stimulating Factor (G-CSF)
| Specifications | |
|---|---|
| Molecular Weight: | 18,8 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 0.060 ng/mL |
| Activity Assay: | NFS-60 cell proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 20 mM Acetic Acid, 50 mM Sodium Chloride |
| Additional Information | |
|---|---|
| Synonyms: | CSF-3, MGI-1G, GM-CSFβ, pluripoietin |
| Organism: | Human |
| Accn. No.: | P09919 |
Sequence Information
MTPLGPASSL PQSFLLKCLE QVRKIQGDGA ALQEKLCATY KLCHPEELVL LGHSLGIPWA PLSSCPSQAL QLAGCLSQLH SGLFLYQGLL QALEGISPEL GPTLDTLQLD VADFATTIWQ QMEELGMAPA LQPTQGAMPA FASAFQRRAG GVLVASHLQS FLEVSYRVLR HLAQP
Background
Granulocyte-colony stimulating factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by bacterial endotoxins, tumor necrosis factor alpha (TNFα), interleukin 1 (IL-1), or interleukin 17 (IL-17). The functional activity of G-CSF is mediated through the granulocyte colony-stimulating factor receptor (G-CSF-R) to activate JAK/STAT and MAPK signal transduction pathways. G-CSF also promotes neurogenesis and inhibits neuronal apoptosis. Human and mouse G-CSF proteins are cross-reactive.
Price
223,00 €
