Human Amphiregulin (AREG)
| Specifications | |
|---|---|
| Molecular Weight: | 10,1 |
| Tag: | None |
| Source: | E.coli |
| Purity: | ≥95% |
| Activity: | 20 ng/mL |
| Activity Assay: | 3T3 Cell Proliferation |
| Format: | Lyophilized from a 0.2 µm filtered solution containing 10 mM Sodium Phosphate, pH 7.5 |
| Additional Information | |
|---|---|
| Synonyms: | AR, AREG, Colorectum cell-derived growth factor, CRDGF |
| Organism: | Human |
| Accn. No.: | P15514 |
Sequence Information
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMK
Background
Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family. AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis. In a cancer context, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the Hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia.
- Catalog Number
100-206AF-10UG-SHE - Supplier
Fujifilm Biosciences - Size
- Shipping
RT
Price
103,00 €
