Anti-Phosphatidyl-Serine-IgG/IgM ELISA

Antibodies against phosphatidyl-serine, an acidic phospholipid derived from glycerol, belong to the group of anti-phospholipid antibodies specific for phospholipids such as cardiolipin, phosphatidyl- inositol, -ethanolamin, -choline, sphingomyelin and phosphatidic acid. Phospholipids are components of biological membranes. Anti-phospholipid antibodies are frequently found in sera of subjects with systemic lupus erythematosus (SLE) and related diseases. The occurrence of anti-phospholipid antibodies in subjects with SLE and related diseases is typical for a secondary anti-phospholipid syndrome (APS). In contrast, antiphospholipid antibodies in people with no other autoimmune diseases characterize the primary APS.  Many studies have shown a correlation between these autoantibodies and an enhanced incidence of thrombosis, thrombocytopenia and habitual abortions (as a consequence of placental infarction). The exact mechanisms by which pathogenic anti-phospholipid antibodies induce thrombosis is not yet revealed fully.