Recombinant Mouse IFNAR1 Protein (His Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 29.36 kDa |
| Tag: | N-His |
| Source: | E.coli |
| Purity: | >85 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Activity: | Testing in progress |
| Format: | Lyophilized from sterile PBS, pH 7.4. |
| Additional Information | |
|---|---|
| Synonyms: | Interferon alpha/beta receptor 1;IFN-R-1 IFN-alpha/beta receptor 1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;CRF2-1;Type I interferon receptor 1;IFNAR |
| Organism: | Mouse |
| Accn. No.: | P33896-1 |
Sequence Information
Glu27-Cyc284
Background
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2 . Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Price
112,00 €
