Recombinant Human AGRP Protein(Trx Tag)
| Specifications | |
|---|---|
| Molecular Weight: | 32.2 kDa |
| Tag: | N-Trx |
| Source: | E.coli |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Format: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Additional Information | |
|---|---|
| Synonyms: | Agouti related neuropeptide;Agouti Related Protein Homolog;Agouti-related protein;Agrp;AGRP;AGRT;ART;ASIP2 |
| Organism: | Human |
| Accn. No.: | O00253 |
Sequence Information
Ala21-Thr132
Background
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with an perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
Price
284,00 €
