H+K+-ATPase Activity Assay Kit

H+K+-ATPase is a member of the P-type ATPase family and mediates the exchange and transport of intracellular hydrogen ions and extracellular potassium ions. Gastric H+K+-ATPase (HKAg) mainly exists in gastric mucosal wall cells and a small amount in renal medulla. As a membrane-bound protein, HKAg has the function of acidifying gastric contents and activating pepsin, and can be used as a therapeutic target for peptic ulcer disease. However, colonic HKA (HKAc) exists in the colon or other tissues and mediates the reabsorption of active K.