PE/Cyanine5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
| Specifications | |
|---|---|
| Clonality: | Monoclonal |
| Clone Name: | FJK-16s |
| Host: | Rat |
| Reactivity: | Mouse, Rat |
| Isotype: | Rat IgG2a, κ |
| Label: | PE/Cyanine5 |
| Concentration: | 0.2 mg/mL |
| Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Applications
ICFCM
Background
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
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