PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody[G043H7]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | G043H7 |
| Host: | Mouse |
| Reactivity: | Human |
| Isotype: | Mouse IgG2a, κ |
| Label: | PE/Cyanine5.5 |
| Concentration: | 5 uL/Test |
| Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Applications
FCM
Background
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Na?ve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.
- Catalog Number
E-AB-F1159I-100Testsx2-ELS - Supplier
Elabscience - Size
- Shipping
Blue Ice
- Price
- Please inquire
