FITC Anti-Mouse CD279/PD-1 Antibody[29F.1A12]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | 29F.1A12 |
| Host: | Rat |
| Reactivity: | Mouse |
| Isotype: | Rat IgG2a, κ |
| Label: | FITC |
| Concentration: | 0.5 mg/mL |
| Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Applications
FCM
Background
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Price
178,00 €
