Elab Fluor® 647 Anti-Mouse CD103 Antibody[M290]
| Specifications | |
|---|---|
| Type: | Primary Antibody |
| Clonality: | Monoclonal |
| Clone Name: | M290 |
| Host: | Rat |
| Reactivity: | Mouse |
| Isotype: | Rat IgG2a, κ |
| Label: | Elab Fluor® 647 |
| Concentration: | 0.5 mg/mL |
| Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Applications
FCM
Background
CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Price
197,00 €
