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Swift Biosciences

  • High complexity NGS libraries
  • DNA input as low as 10 pg
  • Suitable for FFPE and circulating cell-free DNA
  • Targeted sequencing of limited samples

Swift Biosciences specializes in sample preparation for next generation sequencing (NGS). Their products are designed to help customers analyze samples faster, easier, and with greater sensitivity and accuracy while being compatible with leading instrumentation. The proprietary Adaptase adapter attachment chemistry minimizes bias and supports DNA inputs as low as 10 pg and from sources as challenging as FFPE and liquid biopsies.

DNA Library Kits Designed for Illumina NGS Platforms

Swift's highly efficient adapter ligation technologies minimize base composition bias and fidelity issues while also reducing the input requirements. Accel-Amplicon Panels offer a 2 hour, single-tube solution to library preparation for targeted panels. The Accel-NGS 1S Plus DNA Library Kit, which can capture single-stranded DNA molecules and the Accel-NGS 2S Plus DNA Library Kit, designed for intact double-stranded DNA, employ a unique adapter technology which adds Illumina sequencing adapters in an extremely efficiently manner. The Accel-NGS Methyl-Seq DNA Library Kit efficiently constructs libraries from bisulfite-converted DNA. These kits enable Illumina users to produce high complexity libraries for many NGS applications from a variety of sample types and input levels.

Selection Guide

  Exome / Hyb Enrichment Targeted Panels Whole Genome Seq Meta-genomics ChIP-Seq Bisulfite Sequencing
2S Hyb

Compatible with:
· Agilent SureSelect
· NimbleGen SeqCap
· IDT Lockdown

Accel-Amplicon Panels Accel-NGS
2S PCR-Free
- Accel-NGS
2S Plus
Cell-free DNA
Circulating Tumor Cells
dsDNA Only Accel-NGS
2S PCR-Free
ssDNA Only Accel-NGS
1S Plus
1S Plus
1S Plus
1S Plus
ssDNA and dsDNA
Ancient DNA - -

*PCR-free capability is determined by sample quality and input quantity. Accel-NGS 2S PCR-free libraries can be generated from as low as 100 ng of high-quality genomic DNA (for <100 ng, inputs, see Accel-NGS 2S DNA Library Kit for PCR-Free Libraries from 100 ng Input Technical Note, or 10 ng of circulating, cell-free DNA.

**Accel-NGS 1S Plus will not retain DNA fragments that contain uracil, due to DNA damage. To retain these fragments, please use the Accel-NGS Methyl-Seq Kit.

Swift 2S Turbo Library Kits

The Swift 2S Turbo DNA Library Kits offer a versatile solution to streamline NGS sample preparation of dsDNA for sequencing on Illumina® platforms. The technology provides rapid enzymatic DNA fragmentation and library construction for the production of high-quality whole genome and exome libraries using a broad range of input amounts and sample types for sequencing across all Illumina instrument types.

DNA Library Kit Designed for Ion Torrent Platforms

Ion Torrent users can now produce PCR-free libraries with as little as 5 ng of input DNA. Swift's highly efficient adaptation technology reduces the need for PCR, thereby minimizing base composition bias and fidelity issues while also reducing the input requirement. The unique, sequential adaptation process also reduces adapter dimer formation to maximize sequencing output.

Unlike other kits, the Accel-NGS DNA Library Kit for Ion Torrent does not require intact double-stranded DNA, because it has been developed, optimized and validated for samples containing degraded and damaged DNA.

  FFPE Nicked DNA Double-Stranded DNA Single-Stranded DNA Heat Denatured Samples
ChIP-Seq Accel-NGS DNA Library Kit for Ion Torrent
Amplicon Sequencing
Whole Genome Sequencing

Product Citations

Accel Amplicon Panels

Accel-NGS 1S Plus DNA Library Kit

Accel-NGS 2S Plus DNA Library Kit

Accel-NGS 2S Hyb DNA Library Kit

Accel-NGS 2S PCR-Free DNA Library Kit

Accel-NGS Methyl-Seq DNA Library Kit

NGS Overview

Next Generation Sequencing Kits and Services

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