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ACROBiosystems Immune Checkpoint Proteins

ACROBiosystems has developed an exclusive immune checkpoint protein collection. These products have demonstrated consistent and excellent performance in a variety of assays.

2B4 4-1BB 4-1BB Ligand B7-1 B7-2
B7-H2 B7-H3 B7-H3 4Ig B7-H4 B7-H5
B7-H6 B7-H7 BTLA BTN1A1 BTN3A1
BTN3A3 CD155 CD160 CD161 CD229
CD27 CD27 Ligand CD28 CD30 CD30 ligand
CD40 CD40 Ligand CD47 CD48 CD84
CD96 CTLA-4 DNAM-1 Galectin-9 GITR
GITR Ligand HVEM ICOS ILDR2 LAG-3
LAIR-1 LAIR-2 LIGHT LILRB1 LILRB2
LILRB3 LILRB4 LILRB5 MARCO Nectin-1
Nectin-2 Nectin-3 Nectin-4 NTB-A OX40
OX40 Ligand PD-1 PD-L1 PD-L2 PVRIG
SIRP alpha SIRP alphaV2 SIRP gamma SLAMF1 SLAMF7
TIGIT TIM-3 TREM2

Tagged and Untagged Immune Checkpoint Proteins

We provide a comprehensive collection of immune checkpoint proteins. We offer Fc-tagged, His-tagged, Strep-tagged, and/or tag free versions of these proteins. In addition to human proteins, we also offer mouse, rat, rabbit, rhesus macaque, and cynomolgus proteins for your experimental animal studies.

High Quality Materials

The consistency in purity and bioactivity is essential for recombinant proteins. All ACROBiosystems proteins have to go through stringent purity and bioactivity assessment in a variety of assays. Common standards include:

  • Purity greater than 90% by SDS-PAGE and SEC-HPLC
  • Bioactivity validated in functional ELISA
  • Endotoxin less than 1EU/µg by the LAL method
HPLC PAGE

Fig. 1 The purity of Human PD-L1 (Cat# PD1-H5229) was >95% as determined by SEC-HPLC and >98% as determined by SDS-PAGE.

Functional ELISA

Fig. 2 Bioactivity of PD1 (Cat# PD1-H5221-AC) was measured in a functional ELISA against human PDL1 (Cat# PD1-H5258-AC).

Biotin-labeled Proteins

Biotin labeling can make your assay development much easier. We offer a variety of ready-to-use biotinylated checkpoint proteins. These proteins are produced using our in-house developed labeling techniques, which confers high bioactivity and minimal batch-to-batch variation.

Inhibitor Screening Kit Available

We are now offering a PD1-PD-L1 Inhibitor Screening Assay Kit for rapid and high throughput screening of candidate inhibitory antibodies or small molecules of the PD1 pathway.