ACROBiosystems Immune Checkpoint Proteins
ACROBiosystems has developed an exclusive immune checkpoint protein collection. These products have demonstrated consistent and excellent performance in a variety of assays.
Tagged and Untagged Immune Checkpoint Proteins
We provide a comprehensive collection of immune checkpoint proteins. We offer Fc-tagged, His-tagged, Strep-tagged, and/or tag free versions of these proteins. In addition to human proteins, we also offer mouse, rat, rabbit, rhesus macaque, and cynomolgus proteins for your experimental animal studies.
High Quality Materials
The consistency in purity and bioactivity is essential for recombinant proteins. All ACROBiosystems proteins have to go through stringent purity and bioactivity assessment in a variety of assays. Common standards include:
- Purity greater than 90% by SDS-PAGE and SEC-HPLC
- Bioactivity validated in functional ELISA
- Endotoxin less than 1EU/µg by the LAL method
Fig. 1 The purity of Human PD-L1 (Cat# PD1-H5229) was >95% as determined by SEC-HPLC and >98% as determined by SDS-PAGE.
Fig. 2 Bioactivity of PD1 (Cat# PD1-H5221-AC) was measured in a functional ELISA against human PDL1 (Cat# PD1-H5258-AC).
Biotin labeling can make your assay development much easier. We offer a variety of ready-to-use biotinylated checkpoint proteins. These proteins are produced using our in-house developed labeling techniques, which confers high bioactivity and minimal batch-to-batch variation.
Inhibitor Screening Kit Available
We are now offering a PD1-PD-L1 Inhibitor Screening Assay Kit for rapid and high throughput screening of candidate inhibitory antibodies or small molecules of the PD1 pathway.