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Home -> Genomics -> Nucleosomes -> Recombinant Nucleosomes with histone modifications (Designer Nucleosomes)

Recombinant Nucleosomes with histone modifications (Designer Nucleosomes)

• Low lot-to-lot variability and high purity
• Physiologically relevant substrates in enzyme screening assays or for effector protein binding experiments
• Free from DNA which could alter assayed conditions
• Generated by NCL (Native Chemical Ligation) for in vitro biochemical assays with highest reliability

EpiCypher´s human recombinant designer nucleosomes (dNucs) contain defined specific post-translational modifications (PTMs), including lysine acetylation and lysine methylation.
These reagents represent a powerful new technology - critical in understanding chromatin biology and for the development of novel drug targets and precision therapeutics. Of the two currently used synthetic methods, native chemical ligation (NCL) yields superior nucleosome preparations compared to methyllysine analog (MLA). Whereas MLA attempts to mimic the native methyllysine, NCL allows for incorporation of the actual PTM and is not limited to methyllysine.

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dNucs are available with the following PTMs:

K methyl (me1 / me2 / me3)
R methyl (me1 / me2a / me2s)
K acyl (ac / bu / cr)
S phos (H3 S10phos)
Citrulline (H3 Cit2,8,18)
K ubiquityl (H2A ub)


Related Links

Recombinant Epigenetic Reader Domains
Recombinant Histone Methyltransferases

 

 

Description Cat# Size Price    
Nucleosome, Recombinant Human, H2B K120ub dNuc, Biotinylated 16-0370-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 R2me1 dNuc, Biotinylated 16-0340-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 R2me2a dNuc, Biotinylated 16-0341-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me1 dNuc, Biotinylated 16-0321-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me2 dNuc 16-1334-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me2 dNuc, Biotinylated 16-0334-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me3 dNuc 16-1316-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me3 dNuc, Biotinylated 16-0316-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K4me3, K9,14,18ac dNuc, Biotinylated 16-0335-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K9ac dNuc 16-1314-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K9ac dNuc, Biotinylated 16-0314-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K9me1 dNuc, Biotinylated 16-0325-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K9me2 dNuc, Biotinylated 16-0324-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K9me3 dNuc, Biotinylated 16-0315-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 S10phos dNuc, Biotinylated 16-0345-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K14ac dNuc, Biotinylated 16-0343-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K18cr dNuc, Biotinylated 16-0337-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27ac dNuc 16-1365-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27ac dNuc, Biotinylated 16-0365-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27me1 dNuc, Biotinylated 16-0338-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27me2 dNuc, Biotinylated 16-0339-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27me3 dNuc 16-1317-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K27me3 dNuc, Biotinylated 16-0317-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K36me1 dNuc, Biotinylated 16-0322-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K36me2 dNuc 16-1319-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K36me2 dNuc, Biotinylated 16-0319-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K36me3 dNuc 16-1320-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 K36me3 dNuc, Biotinylated 16-0320-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc 16-1362-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc, Biotinylated 16-0362-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 Tetraacetyl (H3 K4,9,14,18ac) dNuc, Biotinylated 16-0336-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H3 Tetraacetyl K4,9,14,18ac/H4 Tetraacetyl K5,8,12,16ac dNuc, Biotinylated 16-0374-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 K12ac dNuc, Biotinylated 16-0312-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 K20me1 dNuc, Biotinylated 16-0331-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 K20me2 dNuc, Biotinylated 16-0332-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 K20me3 dNuc 16-1333-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 K20me3 dNuc, Biotinylated 16-0333-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 Tetraacetyl (H4 K5, 8, 12, 16ac) dNuc 16-1313-EPC 50 ug 657 € DETAILS   Add to Cart 
Nucleosome, Recombinant Human, H4 Tetraacetyl (H4 K5, 8, 12, 16ac) dNuc, Biotinylated 16-0313-EPC 50 ug 657 € DETAILS   Add to Cart 

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