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Home -> Genomics -> Nucleosomes -> Recombinant Nucleosomes as Substrates for Chromatin Remodeling Assays

Recombinant Nucleosomes as Substrates for Chromatin Remodeling Assays

HTS-compatible nucleosome remodeling assays for drug discovery research-
study ATP-dependent chromatin remodeling enzymes using EpiDyne substrates:

• Inhibitor screening and development
• Structure-Activity relationship assays
• Biochemical profiling of ATPase family proteins

Chromatin remodeling regulates DNA access on chromatin and thus impacts gene expression and genome repair. Many ATP-dependent chromatin remodeling enzymes are associated with human disease but are challenging targets to study biochemically due to the requirement for nucleosome-based substrates. EpiCypher has addressed this need by developing EpiDyne, a family of recombinant nucleosome substrates to monitor chromatin remodeling activity in vitro.

EpiDyne nucleosome substrates are available for two readouts: Restriction Enzyme Accessibility (REA) and FRET. DNA only components for both assay types are also available (negative and positive DNA controls for REA and DNA component only of the FRET assay).

EpiDyne-based assays can be used to target SWI/SNF family ATPase complexes (e.g. SMARCA2 or SMARCA4), which are highly associated with numerous types of cancer, when mutated or disregulated.

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Description Cat# Size Price    
EpiDyne, Nucleosome Remodeling Assay Substrate ST601-GATC1 (REA Restriction Enzyme Accessibility Assay) 16-4101-EPC 50 ug 601 € DETAILS   Add to Cart 
EpiDyne, Nucleosome Remodeling Assay Substrate ST601-GATC1, Biotinylated (REA Restriction Enzyme Accessibility Assay) 16-4111-EPC 50 ug 623 € DETAILS   Add to Cart 
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 (Negative Control for REA) 18-4100-EPC 50 ug 130 € DETAILS   Add to Cart 
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 (Negative Control for REA), Biotinylated 18-4110-EPC 50 ug 130 € DETAILS   Add to Cart 
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 (Positive Control for REA) 18-4101-EPC 50 ug 130 € DETAILS   Add to Cart 
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 (Positive Control for REA), Biotinylated 18-4111-EPC 50 ug 130 € DETAILS   Add to Cart 
EpiDyne, Nucleosome Remodeling Assay Substrate (FRET Assay) 16-4201-EPC 50 ug 657 € DETAILS   Add to Cart 
EpiDyne Remodeling Assay Substrate DNA (FRET) 18-4201-EPC 50 ug 130 € DETAILS   Add to Cart 
ACF Chromatin Remodeling Enzyme Complex 15-1013-EPC 100 reactions 367 € DETAILS   Add to Cart 

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