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EpiCypher Nucleosomes - Physiological Substrates for Drug Target Discovery
Nuclesomes are the physiological target of readers, writers and erasers that interact with or modify chromatin. Proteins that write, read or erase ‘histone code’ are mutated in cancer and other diseases making them popular drug targets. The incorporation of nucleosome substrates into drug discovery assays is a dramatic improvement over
peptides, providing access to historically challenging targets.

Nucleosome Structure

Nucleosomes are the basic subunit of chromatin and consist of the histones H2A, H2B, H3 & H4 (2 each) wrapped with 147 base pairs of DNA.

Recombinant Nucleosomes
Our partner EpiCypher has developed the largest portfolio of fully defined and homogenous purified and recombinant nucleosomes on the market incorporating different histone modifications, site mutations and variants, see links above.

• Low lot-to-lot variability
• High purity
• Physiologically relevant substrates


Nucleosome Substrates provide Access to Novel Drug Targets

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DNA and RNA Purification


Use ISOLATE II Nucleic Acid Isolation Kits for the purification of high-quality DNA and RNA.

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Clone Resources

BioCat Clone Resources

Browse two of the most renowned clone resources of full-length cDNA, ORF, and shRNA clones as well as siRNA and yeast knockout strains.

Genome Engineering

Genome Engineering

Use the CRISPR/Cas9 SmartNuclease System to edit the genome.

ExoQuick and ExoQuick-TC

ExoQuick Exosome Isolation

Benefit from the most cited exosome isolation reagent for efficient exosome isolation and exosomal RNA purification from biofluids or culture media.

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