- Nucleosome Components and Subunits
- Purified Nucleosomes
- Recombinant Nucleosome Panels
- Recombinant Nucleosomes
- Recombinant Nucleosomes (Histone Variants)
- Recombinant Nucleosomes (Oncogenic Amino Acid Substitutions)
- Recombinant Nucleosomes as Substrates for Chromatin Remodeling Assays
- Recombinant Nucleosomes with histone modifications (Designer Nucleosomes)
- SNAP-ChIP Panels of barcoded recombinant nucleosomes
Nuclesomes are the physiological target of readers, writers and erasers that interact with or modify chromatin. Proteins that write, read or erase ‘histone code’ are mutated in cancer and other diseases making them popular drug targets. The incorporation of nucleosome substrates into drug discovery assays is a dramatic improvement over
peptides, providing access to historically challenging targets.
Nucleosomes are the basic subunit of chromatin and consist of the histones H2A, H2B, H3 & H4 (2 each) wrapped with 147 base pairs of DNA.
Our partner EpiCypher has developed the largest portfolio of fully defined and homogenous purified and recombinant nucleosomes on the market incorporating different histone modifications, site mutations and variants, see links above.
• Low lot-to-lot variability
• High purity
• Physiologically relevant substrates
Nucleosome Substrates provide Access to Novel Drug Targets