Genome Engineering

• Cas13a ELISA Kits
• Cas9 Activity Assays
• Cas9 Expressing Cell Lines
• Cas9 Protein with Nuclear Localization Signal
• Cas9 Quantitation
• Cas9, dCas9-KRAB, and dCas9-VPH Expressing Cell Lines
• CRISPR Cas9 AAVS1 Safe Harbor Knockin System
• CRISPR Cas9 AAVS1 Safe Harbor Targeting System
• CRISPR Cas9 Guide RNA Custom Constructs
• CRISPR Cas9 Lentiviral Guide RNA Cloning Vectors and Control Constructs
• CRISPR Cas9 Lentiviral Guide RNA Custom Constructs and Libraries
• CRISPR Cas9 Lentiviral Guide RNA Premade Libraries
• CRISPR Cas9 Multiplex Guide RNA Cloning Kits
• CRISPR Cas9 pCAS-Guide Genome Engineering System: Gene-specific Ready-to-Go Knockout Kits
• CRISPR Cas9 pCAS-Guide Genome Engineering System: Vector-based
• CRISPR Cas9 ROSA26 Safe Harbor Targeting System
• CRISPR Cas9 SmartNuclease Genome Engineering System: AAV vector-based for in vivo applications
• CRISPR Cas9 SmartNuclease Genome Engineering System: Lentiviral Vector-based
• CRISPR Cas9 SmartNuclease Genome Engineering System: RNA-based for in vivo applications
• CRISPR Cas9 SmartNuclease Genome Engineering System: Vector-based
• CRISPR Cas9 transEDIT Genome Engineering System: Cas9 Nuclease and Nickase Expression Vectors
• CRISPR Cas9 transEDIT Genome Engineering System: gRNA Cloning Vectors and Negative Controls
• CRISPR Cas9 transEDIT Genome Engineering System: gRNA Target Gene Sets
• CRISPR Cas9 transEDIT Genome Engineering System: Pooled gRNA Libraries
• CRISPR Cas9 transEDIT-dual Genome Engineering System: Dual gRNA Target Gene Sets
• CRISPR Cas9 transEDIT-dual Genome Engineering System: Negative and Positive Controls
• CRISPR/CAS9 Antibodies
• CRISPR/CAS9 RT-PCR Primers
• CRISPRa Lentiviral Guide RNA Premade Libraries
• CRISPRi Lentiviral Guide RNA Premade Libraries
• Custom Clonal Gene Knockout/Editing Cell Line Engineering
• Custom Genome Engineering
• Custom Knockout Cell Line Engineering
• gRNA Synthesis Kits (IVT-based)
• Homologous Recombination Targeting Vectors
• Indel Detection
• Recombinant CAS9 Nucleases and Nickases
• Recombinant Cpf1 Nucleases
• Site-specific Chromatin Loop Formation by dCas9
• ssODN-mediated CRISPR Cas9 System for Gene Deletion, Mutation or Tagging
• Synthetic gRNA
• TALE-Nuclease AAVS1 Targeting
• Transcriptional Activation of endogenous genes by CRISPR/Cas9 SAM
• Transcriptional Activation of endogenous genes by dCas9-VPH
• Transcriptional Repression of endogenous genes by dCas9-KRAB

Powerful Tools for Engineering Genomes
Genome editing technologies using engineered, site-specific nucleases including designer Transcription Activator-Like Effector Nucleases (TALENs) and Cas9/CRISPR-mediated multiplex Genome editing abilities have revolutionized the field of engineering target genomes.
These designed nucleases, when used in combination with Homologous Recombination (HR) targeting vectors, now enable gene knock-outs, knock-ins and even single base Genome editing on demand.