Home -> Genomics -> Gene Silencing -> OriGene HusH 29-mer shRNA Sets (Lentiviral Vector)

OriGene HusH 29-mer shRNA Sets (Lentiviral Vector)


Comprehensive coverage of human, mouse and rat genes
• 29mer shRNA - higher potency
• Lentiviral expression vector
• Guaranteed knockdown (>70%)
• Highly published with over 500 citations
• Each kit contains 4 shRNAs + 1 scrambled control
• Provided as plasmid DNA or pseudoviral particles

With the use of the lentiviral HuSH-29 hairpin constructs, it is now possible to make discoveries with all advantages of lentiviral delivery, like sustained expression and silencing in non-dividing and difficult-to-transfect cells.

The length and design of HuSH-29 hairpin expression constructs is an important improvement over the use of traditional 21mer shRNA and siRNA designs. Longer shRNA constructs appear to enter the RNAi pathway more efficiently and result in much higher potency and specificity than shorter expressed RNAi forms. In most mammalian cells, long double-stranded RNA provokes an interferon response as part of an antiviral defense. This interferon response induces a global shutdown of protein synthesis, thus precluding the use of long double-stranded RNA for specific gene silencing. This obstacle can be overcome by using shRNA less than 30 base pairs in length, which evades the radar of the mammalian interferon response and initiates strong and specific gene silencing. By its optimal length of 29 bases, HuSH-29 has the advantages of improved efficacy and minimal interferon response.

 

 

Description Cat# Size Price    
Human 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs TL3xxxxx-OR 1 set 946 € DETAILS   Add to Cart 
Human 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs, lentiviral particles TL3xxxxxV-GVO-OR 1 set 1617 € DETAILS   Add to Cart 
Mouse 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs TL5xxxxx-OR 1 set 946 € DETAILS   Add to Cart 
Mouse 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs, lentiviral particles TL5xxxxxV-GVO-OR 1 set 1617 € DETAILS   Add to Cart 
Rat 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs TL7xxxxx-OR 1 set 946 € DETAILS   Add to Cart 
Rat 29mer shRNA constructs in lentiviral GFP vector, set of 4 unique constructs, lentiviral particles TL7xxxxxV-GVO-OR 1 set 1617 € DETAILS   Add to Cart 

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