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Ferroptosis

Cell death is essential for life at the cellular level. Apoptosis also known as programmed cell death serves a healthy and protective role in our bodies. Other primary mechanisms of cell death include necrosis, and autophagy, each having a distinct biochemical and morphological footprint. Ferroptosis is a recently recognized form of regulated cell death dependent on iron. The iron mediated form of cell death occurs due to accumulation of lipid reactive oxygen species (ROS) and depletion of plasma membrane polyunsaturated fatty acids. ROS and iron mediated phospholipid peroxidation are the hallmarks of ferroptosis.

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Ferroptosis is morphologically, biochemically, and genetically very distinct from apoptosis, necrosis, and autophagy. To date, ferroptosis has been shown to be involved in cell death associated with Alzheimer´s disease, Huntington disease, cancer, Parkinson´s disease, and kidney degradation. Thus, Ferroptosis has become an attractive target for therapeutic strategy for the treatment of neurological diseases and cancer.

Our partner BioVision is offering a variety of reagents for Ferroptosis research including Ferroptosis inducers, inhibitors and oxidative stress-related assays.


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Ferrostatin, a potent Ferroptosis inhibitor

Related Links

Reactive Oxygen Species (ROS) Detection Assay Kit
Glutathione Assay Kit (GSH, GSSG and Total)
ApoGSH Colorimetric Glutathione Detection Kit
Malondialdehyde ELISA Kit
Flyer Ferroptosis Pathway


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