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Drug Metabolism and Disposition

The disposition of a drug or xenobiotic (any foreign chemical) within a living organism encompasses all reactions/ physiological mechanisms resulting in Absorption, Distribution, Metabolism and Excretion (ADME) of the molecule. ADME influences the concentration and kinetics of exposure to the tissues and hence determines the effects of a given compound. Xenobiotics can be metabolized by various biochemical modifications like oxidation-reduction, hydrolysis, hydration, conjugation, condensation or isomerization, the goal being to make the molecule more hydrophilic and hence easier to excrete.

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A large repertoire of proteins including Cytochrome P450 enzymes, uptake and efflux transporters (P-glycoprotein, MDR transporters), transferases and many other enzymes work in coordination to breakdown and dispose drugs/foreign chemicals in our body resulting in either the desired effects or toxicity.

The below presented Cytochrome 450 Activity Assays are part of BioVisions´ new ADME Product Line, a collection of tools (biochemicals, proteins, antibodies, assay kits) to study various aspects of ADME applicable to drug design, drug metabolism/transport, drug-drug interactions, expression/regulation of expression of drug metabolizing enzymes and transporters, structure-function relationship of target proteins, etc.

For other products of this collection please refer to the links below.
Related Links

Flyer Drug Metabolism Research

 

 

Description Cat# Size Price    
Aromatase (CYP19A) Activity Assay Kit (Fluorometric) K983-100-BV 100 assays 569 € DETAILS   Add to Cart 
Aromatase (CYP19A) Inhibitor Screening Kit (Fluorometric) K984-100-BV 100 assays 599 € DETAILS   Add to Cart 
Beta Amyloid 1- 42 (A beta42) Ligand Screening Assay Kit (Fluorometric) K570-100-BV 100 assays 564 € DETAILS   Add to Cart 
Cytochrome P450 1A2 (CYP1A2) Activity Assay Kit (Fluorometric) K893-100-BV 100 assays 393 € DETAILS   Add to Cart 
Cytochrome P450 1A2 (CYP1A2) Inhibitor Screening Kit (Fluorometric) K894-100-BV 100 assays 442 € DETAILS   Add to Cart 
Cytochrome P450 2C19 (CYP2C19) Activity Assay Kit (Fluorometric) K848-100-BV 100 assays 393 € DETAILS   Add to Cart 
Cytochrome P450 2C19 (CYP2C19) Inhibitor Screening Kit (Fluorometric) K849-100-BV 100 assays 442 € DETAILS   Add to Cart 
Cytochrome P450 2C9 (CYP2C9) Activity Assay Kit (Fluorometric) K895-100-BV 100 assays 393 € DETAILS   Add to Cart 
Cytochrome P450 2C9 (CYP2C9) Inhibitor Screening Kit (Fluorometric) K896-100-BV 100 assays 469 € DETAILS   Add to Cart 
Cytochrome P450 2D6 (CYP2D6) Activity Assay Kit (Fluorometric) K703-200-BV 200 assays 529 € DETAILS   Add to Cart 
Cytochrome P450 2D6 (CYP2D6) Inhibitor Screening Kit (Fluorometric) K704-200-BV 200 assays 635 € DETAILS   Add to Cart 
Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit (Fluorometric) K701-200-BV 200 assays 529 € DETAILS   Add to Cart 
Cytochrome P450 3A4 (CYP3A4) Inhibitor Screening Kit (Fluorometric) K702-200-BV 200 assays 640 € DETAILS   Add to Cart 
Cytochrome P450 Reductase (CPR) Activity Kit (Colorimetric) K700-100-BV 100 assays 601 € DETAILS   Add to Cart 
Multidrug Efflux Transporter (MDR1/P-gp) Ligand Screening Kit K507-100-BV 100 Assays 420 € DETAILS   Add to Cart 
UGT Activity Assay / Ligand Screening Kit (Fluorometric) K692-100-BV 100 assays 458 € DETAILS   Add to Cart 

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